教育背景

1990 – 1994        学士         兰州大学生物系

1996 – 1999        硕士         中国医学科学院,基础医学研究所

1999– 2005       博士         加拿大 University of Alberta

获奖

北京“海聚人才”入选者

加拿大国家蛋白质网络大会优秀青年学者奖（2013）

第八届中国人类蛋白质组学大学优秀青年学者奖 （2013）

发表文章

1. Soliman MA, Abdel Rahman AM, Lamming DA, Birsoy K, Frigolet M, Lu H, Fantus IG, Zheng Y, Sabatini DM, Dennis JW, Pawson T. The adaptor p66Shc inhibits mTOR-dependent anabolic metabolism. Science Signaling, 2014, 7(313): ra 17
• Highlighted in "p66SHC inhibits anabolic metabolism". Zlotorynski E, Nature Reviews Molecular Cell Biology, 2014, 15:222
2. Petschnigg J, Groisman B, Kotlyar M, Taipale M, Zheng Y, Kurat CF, Sayad A, Sierra JR, Mattiazzi-Usaj M, Snider J, Nachmann A, Krykbaeva I, Tsao MS, Moffat J, Pawson T, Lindquist S, Jurisica I, Stagljar I. The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nature Method, 2014 (5):585-92.
3. Pasculescu A, Creixell P*, Schoof EM*, Zheng Y, Olhovsky M, Tian R, So J, Vanderlaan RD, Pawson T, Linding R, Colwill K. CoreFlow: A flexible playground for integration, analysis and modeling of complex biological data. Journal of Proteomics, 2014, pii: S1874-3919(14) 00041-4. (*Equal contribution)
4. Zheng Y, Zhang C, Croucher DR, Soliman MA, St-Denis N, Pasculescu A, Taylor L, Tate SA, Hardy WR, Cowill K, Dai AY, Bagshaw R, Dennis JW, Gingras AC, Daly RJ, Pawson T. Regulation of protein signaling networks by the scaffold protein Shc1 in time and space. Nature, 2013, 499(7457):166-71. Article.
• Nominated in “2013: Signaling Breakthroughs of the Year” by Science Signaling. Berndt JD and Gough NR, 2014, 7:eg1
• Highlighted in “EGF signalling--it's all in SHC1's timing”. Wrighton KH, Nature Reviews Molecular Cell Biology 2013, 14:463
• Recommended as an F1000Prime article by the Faculty of 1000.
5. Ursini-Siegel J, Hardy WR, Zheng Y, Ling C, Zuo D, Zhang C, Podmore L, Pawson T, Muller WJ. The ShcA SH2 domain engages a 14-3-3/PI3'K signaling complex and promotes breast cancer cell survival. Oncogene, 2012, 31(48): 5038-44.
6. Dyson MR, Zheng Y, Zhang C, Colwill K, Pershad K, Kay BK, Pawson T, McCafferty J. Mapping protein interactions by combining antibody affinity maturation and mass spectrometry. Analytical Biochemistry, 2011, 417(1): 25-35.
7. Zhang P*, Zheng Y*, Shi J, Zhang Y, Liu S, Liu Y, Zheng D. Targeting a novel N-terminal epitope of death receptor 5 triggers tumor cell death. Journal of Biological Chemistry, 2010, 285(12):8953-66. (*equal contribution)
8. Shi J, Liu Y, Zheng Y, Guo Y, Zhang J, Cheung PT, Xu R, Zheng D. Therapeutic expression of an anti-death receptor 5 single-chain fixed-variable region prevents tumor growth in mice. Cancer Research, 2006, 66(24):11946-53.
9. Guo Y, Chen C, Zheng Y, Zhang J, Tao X, Liu S, Zheng D, Liu Y. A novel anti-human DR5 monoclonal antibody with tumoricidal activity induces caspase-dependent and caspase-independent cell death. Journal of Biological Chemistry, 2005, 280(51):41940-52.
10. Zheng Y, Liu HZ, Coughlin J, Zheng J, Li L, Stone JC. Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells. Blood, 2005, 105(9):3648-54.
11. Stone JC, Stang SL, Zheng Y, Dower NA, Brenner SE, Baryza JL, Wender PA. Synthetic bryostatin analogues activate the RasGRP1 signaling pathway. Journal of Medical Chemistry, 2004, 47(26):6638-44.
12. Teixeira C, Stang SL, Zheng Y, Beswick NS, Stone JC. Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3. Blood, 2003, 102(4):1414-20.
13. Zheng Y, Qiu C, Hou S, Zhu X, Zheng H, Zhao L, Li G, Liu Y, Liu Y. Evidence for association of D1S249 locus on human chromosome 1 with the susceptibility to essential hypertension in Han Chinese. SCIENCE CHINA Life Sciences, 2001, 44(1):106-12.
14. Qiu C, Zheng Y, Cen W, Zhu X, Liu Y, Cui C, Zuoma C, Chen Y, Chidan L, Pingchuo Z, Zhuang L, Ren D, Cai D, Gesang L, Liu Y, Wu Z, Zhou W. Analyses on the association of CA-repeat polymorphism and A1166C variant in the 3'-flanking region of AT(1)R gene with essential hypertension in Tibetans. Chinese Journal of Medical Genetics, 2000, 17(6):381-5.
15. Liu Y, Zheng Y, Qiu C. Gene Polymorphisms of essential hypertension in Chinese Han population. Chinese Medical Journal, 1999, 2:100-04.
16. Zheng Y, Liu Y, Zhu X, Qiu C. The microsatellite polymorphism at AT1R locus in Chinese Han and Tibetan populations. Chinese Medical Journal, 1999, 11:38-42.
17. Zheng DX, He YP, Liu YX, Zheng Y, Xiao S, Liu Y and Liu SL. Two tyrosines in CD3?-ITAM are required to induce T lymphocyte apoptosis, Chinese Science Bulletin, 1998, 43(17):1480-5.
18. Zheng DX, Zheng Y, Li YX, Liu SL, Perkins D, Terhorst C. T lymphocyte apoptosis induced by CD8? chimera. Chinese Science Bulletin, 1997, 42(3):222-6.
19. Zheng Y, Yuan Q, Liu YX. Studies on the apoptotic gene Fas. Foreign Medical Sciences-Immunology Fascicle, 1996, 5:130-4. Review.
20. Lin Z, Chang L, Zheng Y, Lin ZL, The Identification and Characterization of Bacteriophages of Glutamate-producing Strains. Acta of Yantai University, 1995, 22(3):26-30

 

章节

1. Zheng DX, Zheng Y. “Antibody, T cell receptor and major histocompatibility complex” in “Protein and Nucleic Acid”. Editors Wang LF, Yang KG. Combined Press of Peking Union Medical College and Beijing Medical University, Beijing, 1998. ISBN 7-81034-791-8 (in Chinese)

2. Zheng DX, Zheng Y, He YP. Molecular mechanisms of T lymphocyte apoptosis mediated by CD3, in “Programmed Cell Death”, editors Shi YB, Shi YF, Xu YH, Scott D. Plenum Press, New York, 1997. ISBN 0-306-45680-

专利

1. 抗人死亡受体DR5单克隆抗体AD5-10所识别的抗原决定簇、其衍生物及其用途；
   US20120271034A1\ EP2415781A1\CN102066403A
2. 利用接头蛋白介导的蛋白质相互作用网络的定量变化对疾病进行分类的方法
   （ US patent serial no. 61/779847）

墙报

1. Scaffold protein-mediated signaling network quantification. Posttranslational Modification Networks, Gordon Conference 2013, Hong Kong, China
2. Signaling in time and space. Protein Kinases & Protein Phosphorylation, FASEB conference 2013, Niagara Falls, New York, USA
3. Spatial-temporal analysis of protein signaling networks by scheduled MRM. 4th Annual Canadian National Proteomics Network, 2012, Toronto, Canada
4. Regulation of protein signaling networks by the scaffold protein Shc1 in time and space. HUPO 2011, Geneva, Switzerland
5. SWATH-MS: Data independent capture of MS/MS sequences for quantification of peptide kinetics in a cell signaling cascade. ASMS 2011, Denver, USA
6. Dynamic analysis of the scaffold protein Shc1-mediated signaling network by targeted proteomics. ASMS 2011, Denver, USA
7. Selection of MRM transitions for the development of scheduled multiple reaction monitoring (sMRM) methods to monitor a phosphorylation mediated dynamic cell signaling cascade. HUPO 2010, Sydney, Australia
8. Linking PKC and ras signaling systems by regulatory phosphorylation of RasGRP3 on Threonine 133 in B cells. Immunet, 2005, Edmonton, Canada.
9. Regulation of RasGRP3 activity by PKC-dependent phosphorylation. The 12th International Congress of Immunology and 4th Annual Conference of FOCIS, 2004, Montréal, Canada.
10. Phosphorylation of Thr133 is required for RasGRP3 activation. Department of Biochemistry Retreat, 2003, Jasper, Canada