赵群   博士，助理研究员

中国科学院大连化学物理研究所，生物技术部1810组

大连市中山路457号

Email:   zhaoqun@dicp.ac.cn

教育经历

2004-2008 西北大学，化学系 学士

2008-2014 中国科学院大学，中国科学院大连化学物理研究所 博士

研究经历

2014-至今 助理研究员 中国科学院大连化学物理研究所

一直从事膜蛋白质样品预处理和分离分析新技术与新方法的研究。主要包括：系统研究了离子液体与膜蛋白质相互作用机理， 发展了基于离子液体的膜蛋白质样品预处理方法，显著地提高了膜蛋白质的分析能力；构建并发展了基于“膜”和“双相柱”为载体的微量样品预处理平台及方法， 能够有效地提高微量膜蛋白质样品预处理的效率、回收率及通量。

最近5年发表文章

  1. Qun Zhao, Fei Fang, Ci Wu, Qi Wu, Yu Liang, Zhen Liang, Lihua Zhang, Yukui Zhang, imFASP: An integrated approach combining in-situ filter-aided sample pretreatment with microwave-assisted protein digestion for fast and efficient proteome sample preparation, Anal. Chim. Acta., 2016, 912, 58-64.
  2. Yan Dong, Qun Zhao (Co-aurher), Xiaoyan Ma, Guowu Ma, Caiyun Liu, Zhuwen Chen, Liyuan Yu, Xuefeng Liu, Yanguang Zhang, Shujuan Shao, Jing Xiao, Jia Li, Weimin Zhang, Ming Fu, Lijia Dong, Xiandong Yang, Xu Guo, Liyan Xue, Fei Fang, Qimin Zhan, Lihua Zhang (前两位作者为共同第一作者)，Establishment of a new OSCC cell line derived from OLK and identification of malignant transformation- related proteins by differential proteomics approach, Sci. Rep., 2015, 5, 12668.
  3. Qun Zhao, Fei Fang, Yu Liang, Huiming Yuan, Kaiguang Yang, Qi Wu, Zhen Liang, Lihua Zhang, Yukui Zhang, 1-dodecyl-3-methylimidazolium chloride-assisted sample preparation method for efficient integral membrane proteome analysis, Anal. Chem., 2014, 86, 7544-7550.
  4. Qun Zhao, Yu Liang, Huiming Yuan, Zhigang Sui, Qi Wu, Zhen Liang, Lihua Zhang, Yukui Zhang, Biphasic Microreactor for Efficient Membrane Protein Pretreatment with a Combination of Formic Acid Assisted Solubilization, On-Column pH Adjustment, Reduction, Alkylation, and Tryptic Digestion, Anal. Chem., 2013, 85, 8507–8512.
  5. Qun Zhao, Liangliang Sun, Yu Liang, Qi Wu, Huiming Yuan, Zhen Liang, Lihua Zhang, Yukui Zhang, Prefractionation and separation by C8 stationary phase: Effective strategies for integral membrane proteins analysis, Talanta, 2012, 88, 567-572.
  6. Liyuan Zhang, Qun Zhao, Zhen Liang, Kaiguang Yang, Liangliang Sun, Lihua Zhang, Yukui Zhang, Synthesis of adenosine functionalized metal immobilized magnetic nanoparticles for highly selective and sensitive enrichment of phosphopeptides, Chem. Commun., 2012, 48, 6274-6276.
  7. Liangliang Sun, Qun Zhao, Guijie Zhu, Yuan Zhou, Tingting Wang, Yichu Shan, Kaiguang Yang, Zhen Liang, Lihua Zhang, Yukui Zhang, Octyl-functionalized hybrid magnetic mesoporous microspheres for enrichment of low-concentration peptides prior to direct analysis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, Rapid Commun. Mass Spectrom., 2011, 25, 1257-1265.
  8. Qi Wu, Qun Zhao, Zhen Liang, Yanyan Qu, Lihua Zhang, Yukui Zhang, NSI and NSMT: usages of MS/MS fragment ion intensity for sensitive differential proteome detection and accurate protein fold change calculation in relative label-free proteome quantification, Analyst, 2012, 137, 3146-3153.
  9. Yu Liang, Ci Wu, Qun Zhao, Qi Wu, Bo Jiang, Yejing Weng, Zhen Liang, Lihua Zhang, Yukui Zhang, Gold nanoparticles immobilized hydrophilic monoliths with variable functional modification for highly selective enrichment and on-line deglycosylation of glycopeptides, Anal. Chim. Acta., 2015, 900, 83-89.
  10. Bo Jiang, Kaiguang Yang, Qun Zhao, Qi Wu, Zhen Liang, Lihua Zhang, Xiaojun Peng, Yukui Zhang, Hydrophilic immobilized trypsin reactor with magnetic graphene oxide as support for high efficient proteome digestion, J. Chromatogr. A, 2012, 1254, 8-13.
  11. Ci Wu, Yu Liang, Qun Zhao, Yanyan Qu, Shen Zhang, Qi Wu, Zhen Laing, Lihua Zhang, Yukui Zhang, Boronate affinity monolith with gold nanoparticles modified hydrophilic polymer as matrix for highly specific capture of glycoproteins, Chem. Eur. J., 2014, 20, 8737-8743

专利

  1. 双相柱膜蛋白质微反应器及其应用, 201210349969.0 (已授权)； PCT/CN2013/076942
  2. 一种生物样品纯化装置及其应用, 201310237476.2
  3. 溶液样品中含长烷基链的离子液体的去除方法及其应用, 201310237458.4； PCT/CN2013/ 090129
  4. 基于二级质谱的全离子监测定量方法及应用, 201510392011.3
  5. 一种基于离子液体的蛋白质组样品快速预处理方法, 201510388392.8
  6. 一种细胞膜蛋白质富集纯化方法, 201310557138.7
  7. 一种糖蛋白质富集纯化方法, 201310687406.7
  8. 一种蛋白质样品原位快速预处理方法, 201310105940.2

学术活动

  1. CNHUPO青年学者委员会会员
  2. Analytical and Bioanalytical Chemistry杂志审稿人