钟传奇

教育经历

2000年-2004年 武汉大学 生命科学学院 学士

2004年-2009年 武汉大学 生命科学学院 博士

2010年至今 厦门大学 生命科学学院 博士后

科研领域

主要利用定量蛋白组为工具研究TNF介导的信号通路。前期利用SILAC和iTRAQ标记定量磷酸化蛋白组技术，研究和寻找TNF诱导的细胞坏死信号通路中，RIP3激酶的下游底物。目前利用SWATH-MS定量蛋白组技术，研究在TNF诱导的细胞中蛋白复合物的动态解离和组装。

发表文章

  1. Y. Li#, C.Q. Zhong#*, X. Xu, S. Cai, X. Wu, Y. Zhang, J. Chen, J. Shi, S. Lin, and J. Han* (2015). Group-DIA: analyzing multiple data-independent acquisition mass spectrometry data files. Nature methods. (#Co-first author,*Co-corresponding author)
  2. Zhong, C. Q.#, Y. Li#, D. Yang, N. Zhang, X. Xu, Y. Wu, J. Chen and J. Han (2014). "Quantitative phosphoproteomic analysis of RIP3-dependent protein phosphorylation in the course of TNF-induced necroptosis." Proteomics 14(6): 713-724. (#Co-first author)
  3. Wu, X., L. Tian, J. Li, Y. Zhang, V. Han, Y. Li, X. Xu, H. Li, X. Chen, J. Chen, W. Jin, Y. Xie, J. Han* and C. Q. Zhong * (2012). "Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics." Mol Cell Proteomics 11(12): 1640-1651. (*Co-corresponding author)
  4. Han, J., C. Q. Zhong and D. W. Zhang (2011). "Programmed necrosis: backup to and competitor with apoptosis in the immune system." Nat Immunol 12(12): 1143-1149.
  5. Wang, X., Gong Y, Chen Z., Gong B., Xie J., Zhong, C.Q., Wang Q., Diao L., Xu, A., Han, J., Altman A. and Li Y. (2015) “TCR-induced sumoylation of the kinase PKC-0 controls T cell synapse organization and T cell activation.” Nat. Immunol. 2015 Nov;16(11).
  6. Chen, W., J. Wu, L. Li, Z. Zhang, J. Ren, Y. Liang, F. Chen, C. Yang, Z. Zhou, S. S. Su, X. Zheng, Z. Zhang, C. Q. Zhong, H. Wan, M. Xiao, X. Lin, X. H. Feng and J. Han (2015). "Ppm1b negatively regulates necroptosis through dephosphorylating Rip3." Nat Cell Biol 17(4): 434-444.
  7. Huang, Z., S. Q. Wu, Y. Liang, X. Zhou, W. Chen, L. Li, J. Wu, Q. Zhuang, C. Chen, J. Li, C. Q. Zhong, W. Xia, R. Zhou, C. Zheng and J. Han (2015). "RIP1/RIP3 binding to HSV-1 ICP6 initiates necroptosis to restrict virus propagation in mice." Cell Host Microbe 17(2): 229-242
  8. Wu, X., W. T. He, S. Tian, D. Meng, Y. Li, W. Chen, L. Li, L. Tian, C. Q. Zhong, F. Han, J. Chen and J. Han (2014). "pelo is required for high efficiency viral replication." PLoS Pathog 10(4): e1004034.
  9. Tian, L., J. Chen, M. Chen, C. Gui, C. Q. Zhong, L. Hong, C. Xie, X. Wu, L. Yang, V. Ahmad and J. Han (2014). "The p38 pathway regulates oxidative stress tolerance by phosphorylation of mitochondrial protein IscU." J Biol Chem 289(46): 31856-31865.
  10. Chen, W., Z. Zhou, L. Li, C. Q. Zhong, X. Zheng, X. Wu, Y. Zhang, H. Ma, D. Huang, W. Li, Z. Xia and J. Han (2013). "Diverse sequence determinants control human and mouse receptor interacting protein 3 (RIP3) and mixed lineage kinase domain-like (MLKL) interaction in necroptotic signaling." J Biol Chem 288(23): 16247-16261.
  11. Chuan-Qi Z, Shengli S, Nan F, et al. Improvement of low-temperature caseinolytic activity of a thermophilic subtilase by directed evolution and site-directed mutagenesis[J]. Biotechnology & Bioengineering, 2009, 104(5):862–870.
  12. Fang, N., C. Q. Zhong, X. Liang, X. F. Tang and B. Tang (2010). "Improvement of extracellular production of a thermophilic subtilase expressed in Escherichia coli by random mutagenesis of its N-terminal propeptide." Appl Microbiol Biotechnol 85(5): 1473-1481.
  13. Yang, Y. R., H. Zhu, N. Fang, X. Liang, C. Q. Zhong, X. F. Tang, P. Shen and B. Tang (2008). "Cold-adapted maturation of thermophilic WF146 protease by mimicking the propeptide binding interactions of psychrophilic subtilisin S41." FEBS Lett 582(17): 2620-2626.
  14. SHI Wan-liang, ZHONG Chuan-qi, TANG Bing,等. Purification and characterization of extracellular halophilic protease from haloarchaea Natrinema sp.R6-5 极端嗜盐古生菌(Natrinema sp.)R6-5胞外嗜盐蛋白酶的纯化和性质研究[J]. 微生物学报, 2007, 01期:161-163.

参加项目经历

  1. 2011.01.01-2014.12.31，国家自然科学基金委员会重大研究计划项目：小RNA在大肠炎症反应及其向肿瘤转化中的作用，91029304
  2. 2014.01.01-2018.12.31，国家自然科学基金委员会重点项目：肿瘤坏死因子引起细胞坏死的信号通路研究，31330047
  3. 2015.01.01-2019.12.31，国家自然科学基金委员会重点国际(地区)合作研究项目：巨噬细胞中细菌脂多糖信号传导动态过程的系统化和定量化研究，31420103910

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