王恒樑

个人信息

王恒樑，理学博士，军事医学科学院生物工程研究所分子与细胞微生物学研究室主任，病原微生物生物安全国家重点实验室研究员，博士生导师。 1993年毕业于山东大学微生物系微生物学专业，在1996年、1999年分别获军事医学科学院硕士、博士学位，毕业后留院工作至今，主要从事基因工程疫苗和微生物功能基因组学研究。 2006年分别被评为总后勤部和北京市科技新星；2007年被遴选为军事医学科学院第三批军事医学复合人才。 2011年获国家杰出青年科学基金资助，并于2012年初被四总部联合表彰为2011年度全军爱军精武标兵及入选全军高层次科技拔尖人才培养对象。 现承担国家973课题1项、国家863课题1项、国家重大专项新药创制课题1项、国家自然科学基金2项以及军队重大指令性课题1项、军队“十二五”医药卫生重大项目课题1项，另所带领的课题组成员承担国家973、国家重大专项、国家自然基金、军队“十二五”医药卫生项目等课题6项。 所主持的军民两用课题新型痢疾双价活疫苗完成I、II期临床试验，正在进行III期临床试验；主编译专著6部、参编译专著3部，在Mol Cell Proteomics、Proteomics、J Proteome Res等国内外杂志上发表了论文100多篇，其中SCI刊物25篇，总影响因子累计超过100（他引近300次），h因子为9。 现兼任“十二五”国家863计划疫苗重大项目总体专家组成员、军事医学科学院生物工程研究所学术委员会委员、中国微生物学会分析微生物专业委员会委员、中国微生物学会微生物毒素专业委员会委员、中国生物化学与分子生物学会蛋白质组学专业委员会委员等学术职务。 Proteomics、J Proteome Res、BMC genomics、中国科学等国内外杂志的审稿专家。

发表文章

  1. Niu C, Shang N, Liao X, Feng EL, Liu XK, Wang DS, Wang J, Huang PT, Hua YJ, Zhu L, Wang HL*, 'Analysis of soluble protein complexes in Shigella flexneri reveals the influence of temperature on the amount of lipopolysaccharide', Mol Cell Proteomics, 2013, 12(5): 1250-1258.
  2. Liu XK, Wang DS, Ren JX, Tong C, Feng EL, Wang XF, Zhu L, Wang HL*, 'Identification of the immunogenic spore and vegetative proteins of Bacillus anthracis Vaccine Strain A16R', PLoS One, 2013, 8(3): e57959.
  3. Liu XK, Wang DS, Wang HG, Feng EL, Zhu L, Wang HL*, 'Curing of plasmid pXO1 from Bacillus anthracis using plasmid incompatibility', PLoS One, 2012, 7(1): e29875.
  4. Wang HG, Liu XK, Feng EL, Zhu L, Wang DS, Liao XR, Wang HL*, 'Curing the Plasmid pXO2 from Bacillus anthracis A16 Using Plasmid Incompatibility', Curr Microbiol, 2011, 62: 703–709.
  5. Zhu L, Hu W, Liu DT, Tian WH, Yu G, Liu XK, Wang J, Feng EL, Zhang XM, Chen B, Zeng M*, Wang HL*, 'A Reference Proteomic Database of Lactobacillus plantarum CMCC-P0002', PLoS ONE, 2011, 6(10): e25596.
  6. Zhao G, Zhu L, Cao XY, Liu XK, Liao X, Ying TY, Wang J, Feng EL, Chen HP, Wang HL*, 'A novel anti-virulence gene revealed by proteomic analysis in Shigella flexneri 2a', Proteome Sci, 2010, 8:30.
  7. Zhu L, Zhao G, Stein R, Zheng XX, Hu W, Shang N, Bu X, Liu XK, Wang J, Feng EL, Zhang XM, Ye QN, Huang PT, Zeng M, Wang HL*, 'The proteome of Shigella flexneri 2a 2457T grown at 30°C and 37°C', Mol Cell Proteomics, 2010, 9(6): 1209-1220.
  8. Zhu L, Liu XK, Zheng XX, Bu X, Zhao G, Xie CH, Zhang JF, Li N, Feng EL, Wang J, Jiang YQ, Huang PT, Wang HL*, 'Global analysis of a plasmid-cured Shigella flexneri strain: new insights into the interaction between the chromosome and a virulence plasmid', J Proteome Res, 2010, 9: 843-854.
  9. Jing HB, Yuan J, Wang J, Yuan Y，Zhu L, Liu XK, Zheng YL, Wei KH, Zhang XM, Geng HR, Duan Q，Feng SZ，Yang RF, Cao WC, Wang HL*, Jiang YQ, 'Proteome analysis of Streptococcus suis serotype', Proteomics, 2008, 8(2): 333-349.
  10. Geng H, Zhu L, Yuan Y, Zhang W, Li W, Wang J, Zheng Y, Wei K, Cao W, Wang H*, Jiang Y, 'Identification and characterization of novel immunogenic proteins of Streptococcus suis serotype 2', J Proteome Res, 2008, 7(9): 4132-42.
  11. Zhu L, Liu XK, Zhao G, Zhi YD, Bu X, Ying TY, Feng EL，Wang J, Zhang XM, Huang PT, Wang HL*, 'Dynamic proteome changes of Shigella flexneri 2a during transition from exponential growth to stationary phase', Geno Prot Bioinfo, 2007, 5(2): 111-120.
  12. Dong H, Ying TY, Li MZ, Cao TM, Wang JJ, Yuan J, Feng EL，Han BS, Hua FY,Yang Y, Yuan JG, Wang HL*, Xu CM, 'Comparative Proteomic Analysis of Apoptosis Induced by Sodium Selenite in Human Acute Promyelocytic Leukemia NB4 Cells', J Cell Biochem, 2006, 98(6): 1495-1506.
  13. Yuan J, Zhu L, Liu XK, Li T, Zhang Y, Ying TY, Wang B, Wang J, Dong H, Feng EL, Li Q, Wang J, Wang HQ, Wei KW, Zhang XM, Huang CF, Huang PT, Huang LY, Zeng M, Wang HL*, ' A proteome reference map and proteomics analysis of bifidobacterium longum NCC2705', Mol Cell Proteomics, 2006, 5(6): 1105-1118.
  14. Wang JJ, Ying TY, Wang HL*, Shi ZX, Li MZ, He K, Feng ER, Wang J, Yuan J, Li T, Wei KH, Su GF, Zhu HC, Zhang XM, Huang PT, Huang LY, '2-D reference map of Bacillus Anthracis vaccine strain A16R proteins', Proteomics, 2005, 5(17): 4488-4495.
  15. Ying TY*, Wang HL*, Li MZ, Wang JJ, Wang J, Shi ZX, Feng ER, Su GF, Zhang XM, Huang PT, Huang CF, Huang LY, 'Immunoproteomics of outer membrane proteins and extracellular proteins of Shigella flexneri 2a 2457T', Proteomics, 2005, 5(18): 4777-4793.
  16. Ying TY, Wang JJ, Wang HL*, Feng EL, Wei KH, Huang LY, Huang PT, Huang CF, 'Immunoproteomics of membrane proteins of Shigella flexneri 2a 2457T', World J Gastroenterol, 2005, 11(43):6880-6883.