张扬博士,复旦大学生物医学研究院讲师、工程师。1997~2001年就读于浙江大学生物学专业本科;2001~2004年就读于浙江大学生物系生物信息学专业,获得硕士学位;2008~2012年就读于复旦大学生命科学学院生化与分子生物学专业,获得博士学位。2004年至今在复旦大学生物医学研究院蛋白质组学和系统生物学实验室工作,负责生物信息学方面的硬件与软件平台的架设,同时参与以蛋白质组学数据为核心的癌症生物标志物挖掘方法与糖蛋白质组学研究。在糖蛋白质组学研究中利用现有主流的质谱技术,开发了糖肽谱图自动化搜索平台,并在标准品与实际样品的测试中已取得较好的结果,相关软件GRIP已经成形,有望投入到大规模的疾病蛋白质组学中。

发表文章:

  1. 'First Insight into the Human Liver Proteome from Proteome(Sky)-Liver(Hu) 1.0, a Publicly Available Database', Journal of Proteome Research (2009).
  2. H. Bao, P. Song, Q. Liu, Y. Liu, D. Yun, H. Saiyin, R. Du, Y. Zhang, H. Fan, P. Yang, and X. Chen, 'Quantitative Proteomic Analysis of a Paired Human Liver Healthy Versus Carcinoma Cell Lines with the Same Genetic Background to Identify Potential Hepatocellular Carcinoma Markers', Proteomics Clinical Application, 3 (2009), 705-19.
  3. G. Chen, Y. Zhang, X. Jin, L. Zhang, Y. Zhou, J. Niu, J. Chen, and Y. Gu, 'Urinary Proteomics Analysis for Renal Injury in Hypertensive Disorders of Pregnancy with Itraq Labeling and LC-MS/MS', Proteomics Clinical Application, 5 (2011), 300-10.
  4. M. Gao, W. Yu, Y. Zhang, G. Yan, C. Deng, P. Yang, and X. Zhang, 'Integrated Strong Cation Exchange/Capillary Reversed-Phase Liquid Chromatography/on-Target Digestion Coupled with Mass Spectrometry for Identification of Intact Human Liver Tissue Proteins', Analyst, 133 (2008), 1261-7.
  5. Yang Liu Haijian Wang, Wen Tan, Yang Zhang, Naiqing Zhao, Yan Jiang, Chengzhao Lin, Bingtao Hao, Dan Zhao, Ji Qian,  Daru Lu,  Li Jin, Qingyi Wei,  Dongxin Lin  and Fuchu H, 'Association of the Variable Number of Tandem Repeats Polymorphism in the Promoter Region of the Smyd3 Gene with Risk of Esophageal Squamous Cell Carcinoma in Relation to Tobacco Smoking', Cancer Science, 99 (2008 Apr), 787-91.
  6. G. Z. Jin, Y. Li, W. M. Cong, H. Yu, H. Dong, H. Shu, X. H. Liu, G. Q. Yan, L. Zhang, Y. Zhang, X. N. Kang, K. Guo, Z. D. Wang, P. Y. Yang, and Y. K. Liu, 'Itraq-2DLC-ESI-MS/MS Based Identification of a New Set of Immunohistochemical Biomarkers for Classification of Dysplastic Nodules and Small Hepatocellular Carcinoma', Journal of Proteome Research, 10 (2011), 3418-28.
  7. C. Li, Y. Sun, Z. Fang, X. Han, R. Fang, Y. Zhang, Y. Pan, W. Zhang, Y. Ren, H. Ji, and H. Chen, 'Comprehensive Analysis of Epidermal Growth Factor Receptor Gene Status in Lung Adenocarcinoma', J Thorac Oncol, 6 (2011), 1016-21.
  8. X. Long, J. Zhang, Y. Zhang, J. Yao, Z. Cai, and P. Yang, 'Nano-LC-MS/MS Based Proteomics of Hepatocellular Carcinoma Cells Compared to Chang Liver Cells and Tanshinone Iia Induction', Mol Biosyst, 7 (2011), 1728-41.
  9. ChunhuiDeng, MingxiaGao, WenjiaYu,YangZhang,PengyuanYangandXiangminZhang, 'Large Scale Depletion of the High-Abundance Proteins and Analysis of Middle- and Low-Abundance Proteins in Human Liver Proteome by Multidimensional Liquid Chromatography', Proteomics, 8 (2008 Mar), 939-47.
  10. A. Y. Nie, L. Zhang, G. Q. Yan, J. Yao, Y. Zhang, H. J. Lu, P. Y. Yang, and F. C. He, 'In Vivo Termini Amino Acid Labeling for Quantitative Proteomics', Analytical Chemistry, 83 (2011), 6026-33.
  11. P. Song, H. Bao, Y. Yu, Y. Xue, D. Yun, Y. Zhang, Y. He, Y. Liu, Q. Liu, H. Lu, H. Fan, J. Luo, P. Yang, and X. Chen, 'Comprehensive Profiling of Metastasis-Related Proteins in Paired Hepatocellular Carcinoma Cells with Different Metastasis Potentials', Proteomics Clinical Application, 3 (2009), 841-52.
  12. P. M. Song, Y. Zhang, Y. F. He, H. M. Bao, J. H. Luo, Y. K. Liu, P. Y. Yang, and X. Chen, 'Bioinformatics Analysis of Metastasis-Related Proteins in Hepatocellular Carcinoma', World J Gastroenterol, 14 (2008), 5816-22.
  13. C. Sun, C. Song, Z. Ma, K. Xu, Y. Zhang, H. Jin, S. Tong, W. Ding, G. Xia, and Q. Ding, 'Periostin Identified as a Potential Biomarker of Prostate Cancer by Itraq-Proteomics Analysis of Prostate Biopsy', Proteome Science, 9 (2011), 22.
  14. Q. Sun, X. Kang, Y. Zhang, H. Zhou, Z. Dai, W. Lu, X. Zhou, X. Liu, P. Yang, and Y. Liu, 'Dsa Affinity Glycoproteome of Human Liver Tissue', Arch Biochem Biophys, 484 (2009), 24-9.
  15. Ding K Wang H, Zhang Y, Jin L, Kullo IJ, He F., 'Comparative and Evolutionary Pharmacogenetics of Abcb1: Complex Signatures of Positive Selection on Coding and Regulatory Regions.', Pharmacogenet Genomics, 17 (2007 Aug), 667-78.
  16. HuixiaWu, WeitaoJia , HaojieLu ,YangZhang ,RuifangCai and PengyuanYang, 'Rapid and Automatic on-Plate Desalting Protocol for Maldi-Ms:Using Imprinted Hydrophobic Polymer Template', Proteomics, 7 (2007 Aug), 2497-506.
  17. X. Xu, M. Qiao, Y. Zhang, Y. Jiang, P. Wei, J. Yao, B. Gu, Y. Wang, J. Lu, Z. Wang, Z. Tang, Y. Sun, W. Wu, and Q. Shi, 'Quantitative Proteomics Study of Breast Cancer Cell Lines Isolated from a Single Patient: Discovery of Timm17a as a Marker for Breast Cancer', Proteomics, 10 (2010), 1374-90.
  18. Y. Yu, H. Shen, H. Yu, F. Zhong, Y. Zhang, C. Zhang, J. Zhao, H. Li, J. Chen, Y. Liu, and P. Yang, 'Systematic Proteomic Analysis of Human Hepotacellular Carcinoma Cells Reveals Molecular Pathways and Networks Involved in Metastasis', Molecular Biosystem, 7 (2011), 1908-16.