张红雨,教授,博士生导师

   

1988.09-1992.07  山东大学生物系  理学学士

1992.08-1997.01  中国科学院生物物理研究所  理学博士

   

1997.02-1998.10    山东师范大学生命科学学院            讲师

1998.11-2000.06    山东师范大学生命科学学院            教授

2000.07-2009.01     山东理工大学生命科学学院            教授、博导

2009.02至今         华中农业大学生命科学技术学院        教授、博导 

2010.09-2010.10   新加坡南洋理工大学生命科学学院      客座教授

研究方向

系统进化生物学(生命起源进化机制)

系统化学生物学(进化启发的药物发现)

主要兼职

中国空间科学学会空间生命起源与进化专业委员会副主任委员

Current Computer-Aided Drug DesignSCI收录)编委

Neural Regeneration ResearchSCI收录)编委

Genomics Insights编委

Research in Pharmaceutical Biotechnology编委

Open Journal of Genomics编委

   

027-87280877

电子邮件

zhy630@mail.hzau.edu.cn

工作单位

华中农业大学生命科学技术学院/作物遗传改良国家重点实验室/生物信息中心

研究成果

代表性论文:

l  Jiang Y.-Y., Kong D.-X., Qin T., Li X., Caetano-Anollés G., Zhang H.-Y. (2012) The impact of oxygen on metabolic evolution: a chemoinformatic investigation. PLoS Comput. Biol. 8: in press. (corresponding author)

l  Kim K. M., Qin T., Jiang Y.-Y., Chen L.-L., Xiong M., Caetano-Anollés D., Zhang H.-Y., Caetano-Anollés G. (2012) Protein domain structure uncovers the origin of aerobic metabolism and the rise of planetary oxygen. Structure 20: 67-76. (co-corresponding author) (Preview: Saito, M. A. Structure 2012, 20: 1-2) (Featured by Science: http://news.sciencemag.org/sciencenow/2012/01/the-first-oxygen-users.html)

l  Wang Z.-Y., Fu L.-Y., Zhang H.-Y. (2012) Can medical genetics and evolutionary biology inspire drug target identification? Trends Mol. Med. 18: 69-71. (corresponding author) (Featured article)

l  Zhu Q., Qin T., Jiang Y.-Y., Ji C., Kong D.-X., Ma B.-G., Zhang H.-Y. (2011) Chemical basis of metabolic network organization. PLoS Comput. Biol. 7: e1002214. (corresponding author)

l  Wang M., Jiang Y.-Y., Kim K. M., Qu G., Ji H.-F., Mittenthal J. E., Zhang H.-Y., Caetano-Anollés G. (2011) A universal molecular clock of protein folds and its power in tracing the early history of aerobic metabolism and planet oxygenation. Mol. Biol. Evol. 28: 567-582. (co-corresponding author)

l  Zhang H.-Y., Chen L.-L., Li, X.-J., Zhang J. (2010) Evolutionary inspirations for drug discovery. Trends Pharmacol. Sci. 31: 443-448. (corresponding author)

l  Ji H.-F., Chen L., Jiang Y.-Y., Zhang H.-Y. (2009) Evolutionary formation of new protein folds is linked to metallic cofactor recruitment. BioEssays 31: 975-980. (corresponding author)

l  Ji H.-F., Kong D.-X., Shen L., Chen L.-L., Ma B.-G., Zhang H.-Y. (2007) Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery. Genome Biol. 8: R176. (corresponding author)

l  Zhang H.-Y., Sun Y.-M., Wang X.-L. (2003) Substituent effects on O-H bond dissociation enthalpies and ionization potentials of catechols: a DFT study and its implications in rational design of phenolic antioxidants and elucidation of structure-activity relationships for flavonoid antioxidants. Chem. Eur. J. 9: 502-508. (corresponding author)

l  Zhang H.-Y., Sun Y.-M., Wang X.-L. (2002) Electronic effects on O-H proton dissociation energies of phenolic cation radicals. A DFT study. J. Org. Chem. 67: 2709-2712. (corresponding author)

 

   

2011年获得教育部自然科学二等奖(首位)。

2005年获得中国化学会青年化学奖。

1999年获得第三届中国药理学会Servier奖。